TOPICS

2019

2020/2/1

Publications updated.
J. Mao, H. Itoh, K. Sakurai, M. Inoue, "Phospholipid-Dependent Functions of a Macrocyclic Analogue of the Ion-Channel-Forming Antibiotic Gramicidin A," Chem. Pharm. Bull.2020, 68, 173.
DOI: 10.1248/cpb.c19-00967
2020/1/27

Dr. Kamakura recieved a presentation award at 61st Symposium on the Chemistry of Natural Products. Title: Total Synthesis of Talatisamine
2019/12/12

Prof. Inoue recieved "Inoue Prize for Science." Jump from here.
2019/11/28

Prof. Inoue recieved "Tarrant Distinguished Visiting Professorship of Organic Chemistry."
2019/11/5

Joint symposium with Prof. Olofsson lab was held. Pictures are here.
2019/11/1

Publications updated.
D. Kamakura, H. Todoroki, D. Urabe, K. Hagiwara, M. Inoue, "Total Synthesis of Talatisamine," Angew. Chem. Int. Ed. in press.
DOI: 10.1002/anie.201912737
2019/10/25

Our paper "Biological Effects of a Simplified Synthetic Analogue of Ion-Channel-Forming Polytheonamide B on Plasma Membrane and Lysosomes" was selected as Hot Paper of Chemistry A European Journal.
2019/10/18

Dr. Nagatomo has recieved "Chemist Award BCA 2019" from MSD Life Science Foundation.
2019/10/13

Our research "Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E" was featured in the NIKKEI (October 13, 2019).
2019/9/25

Tsukasa Shimakawa (G3) received Oral Presentation Award at The 9th Junior International Conference on Cutting-Edge Organic Chemistry in Asia. Title: "Synthetic Study of Puberuline C"
2019/9/24

Publications updated.
Y.-W. Xue, A. Hayata, H. Itoh, M. Inoue, "Biological Effects of a Simplified Synthetic Analogue of Ion‐Channel‐Forming Polytheonamide B on Plasma Membrane and Lysosomes," Chem. Eur. J. in press.
DOI: 10.1002/chem.201903974
2019/9/10

Publications updated.
D. Kuwana, M. Nagatomo, M. Inoue, "Total Synthesis of 5-epi-Eudesm-4(15)-ene-1β,6β-diol via Decarbonylative Radical Coupling Reaction," Org. Lett. in press.
DOI: 10.1021/acs.orglett.9b02895
2019/9/6

Daiki Kuwana (G4) received Poster Award at The 27nd International Society of Heterocyclic Chemistry Congress. Title: "Installation of O Heterocycles to N Heteroarenes via an Et3B/O2 Mediated Radical Reaction of a Alkoxy and a Alkoxyacyl Tellurides"
2019/8/21

An interview article of Dr. Ken Mukai, a graduate from our laboratory, is published on brochure of The University of Tokyo, Graduate School of Pharmaceutical Scienece. Jump from here.
2019/7/18

Our research "Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E" was featured in the NIKKEI BUSINESS DAILY (July 18, 2019).
2019/7/16

Our paper "Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E" was selected as Nature Communications Editor's Highlights. Jump from here.
2019/7/5

Publications updated.
H. Itoh, K. Tokumoto, T. Kaji, A. Paudel, S. Panthee, H. Hamamoto, K. Sekimizu, M. Inoue, "Development of a high-throughput strategy for discovery of potent analogues of antibiotic lysocin E," Nat. Commun. 2019, 10, 2992.
DOI: 10.1038/s41467-019-10754-4
2019/6/25

Publications updated.
H. Itoh, M. Inoue, "Full solid-phase total synthesis of macrocyclic natural peptides using four-dimensionally orthogonal protective groups," Org. Biomol. Chem. in press.
DOI: 10.1039/C9OB01130G
2019/6/19

Publications updated.
Y. Imamura, S. Yoshioka, M. Nagatomo, M. Inoue, "Total Synthesis of 1‐Hydroxytaxinine," Angew. Chem. Int. Ed. in press.
DOI: 10.1002/anie.201906872
2019/6/17

Akira Hirose (G4) received Poster Award at The 1st International Symposium on Hybrid Catalysis for Enabling Molecular Synthesis on Demand. Title: "Study toward Unified Total Synthesis of Tigliane and Daphnane Diterpenes"
2019/6/4

Koichi Kamiya (G3) received Presentation Award at the 17th Symposium on Organic Chemistry -the Next Generation-. Title: "Unified Solid-Phase Total Synthesis of Yaku'amide B and Its Geometrical Isomers"
2019/5/17

Publication updated.
D. Urabe, M. Inoue, "Convergent Total Synthesis of Bioactive Cardenolides" J. Synth. Org. Chem., Jpn 2019, 77, 452-461.
DOI: 10.5059/yukigoseikyokaishi.77.452
2019/4/25

Prof. Inoue received "Pharmaron Lecture Award". Jump from here
2019/4/22

Student Presentation Award at the 139 th Annual Meeting of the Pharmaceutical Society of Japan.
Toshiya Nagai (G3) "Sythetic Studies on Euonyminol"
Tsukasa Shimakawa (G2) "A Study toward Total Synthesis of Puberuline C"
Yunwei Xue (G2) "Functional Analysis of Polytheonaminde Mimic"
2019/4/5

Publications updated.
H. Itoh, M. Inoue, "Comprehensive Structure–Activity Relationship Studies of Macrocyclic Natural Products Enabled by Their Total Syntheses," Chem. Rev. in press.
DOI: 10.1021/acs.chemrev.9b00063
2019/3/29

Publications updated.
D. Kuwana, B. Ovadia, D. Kamimura, M. Nagatomo, M. Inoue, "Installation of O‐Heterocycles to N‐Heteroarenes via Et₃B/O₂‐mediated Radical Reaction of α-Alkoxy and α-Alkoxyacyl Tellurides," Asian J. Org. Chem. in press.
DOI: 10.1002/ajoc.201900170
2019/2/28

Publications updated.
M. Nagatomo, Y. Fujimoto, K. Masuda, M. Inoue, "Construction of a 6/5/9-membered tricyclic structure of cladiellins via radical-polar crossover reaction," J. Antibiot. in press.
DOI: 10.1038/s41429-019-0150-7
2019/2/27

Our paper "Total Synthesis and Biological Mode of Action of WAP-8294A2: A Menaquinone-Targeting Antibiotic" was selected as the three most read papers in JOC in 2018. Jump from here
2019/1/4

Lecturer Masanori Nagatomo received The Thieme Chemistry Journals Award 2019. Jump from here